GAG MUTATIONS STRONGLY CONTRIBUTE TO HIV-1 RESISTANCE TO PROTEASE INHIBITORS IN HIGHLY DRUG-EXPERIENCED PATIENTS BESIDES COMPENSATING FOR FITNESS LOSS.

Human immunodeficiency virus type 1 (HIV-1) resistance to protease inhibitors (PI) results from mutations in the viral protease (PR) that reduce PI binding but also decrease viral replicative capacity (RC).Additional mutations compensating for the RC loss subsequently accumulate within PR and in Gag substrate cleavage sites.We examined the respecti

This research is aimed to test the influence of perceived compatibility perceived usefulness, perceived ease of use and intention to use smartphone using five hypotheses.Purposive sampling was used as the technique of sample collection.There are representative samples that are 92 respondents, consists of lecturers, students, and employees from AKI

Abstract Aims Heart failure (HF) substantially limits the ability of patients to engage in physical activities.A detailed understanding of how patients experience these limitations is required to develop valid and sensitive measures for use in clinical research.This qualitative study was designed to provide a thorough description of how HF patients

Supply chain as an industry has gone through four-fold changes in the last century.Born as a bare-bones structure in 1.0 it grew to incorporate some form of record preservation in 2.0 and then Entry Guards integrated communication between two entities in 3.0.Supply chain 4.0, the current one, has total global integration of multiple entities with t

Recently, we discovered that alpha satellite DNA has unique and genus-specific localizations on the chromosomes of small apes.This study describes the details of alpha satellite localization in the genera Nomascus and Hylobates and explores their usefulness in distinguishing parental genome sets in hybrids between these genera.Fluorescence in situ